Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Interleukin-7 in rheumatoid arthritis.
Recent data from several groups demonstrate high levels of IL-7 in the joints of RA patients, but much lower levels in OA. In contrast, circulating levels of IL-7 in RA remain a point of debate. IL-7 has many roles in T cell, dendritic cell and bone biology in humans. Reduced levels of circulating IL-7 probably underlie a number of the dysfunctions associated with circulating T cells in RA and ...
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Interleukin-7 (IL-7) is a stromal factor that is crucial for the development of T lymphocytes in humans and mice, and also B lymphocytes in mice. IL-7 can act as a T cell growth factor as well as a critical anti-apoptotic survival factor. The essential non-redundant role of this cytokine for T cell development in vivo is indicated by the phenotype of murine knockout models as well as by humans ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2011
ISSN: 0004-3591
DOI: 10.1002/art.30493